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As a result of of those extra roles, medicine that inhibit COX-1 can cause unwanted negative effects. COX-2 inhibitors are a kind of NSAID that selectively blocks the COX-2 enzyme and not the COX-1 enzyme. The aim of COX-2 inhibitors is to reduce ache and inflammation without shedding the protection of COX-1 in the gastrointestinal tract. This produces fewer gastrointestinal negative effects. In 2005, the Commission revealed a Green Paper - Selling the Mental Health of the Population as a primary response to the World Well being Organization's Psychological Health Declaration for Europe. In 2013, a Joint Action Mental Well being and Properly-being was launched with monetary assist from the EU Health Programme. It is a three-12 months initiative that goals to create a framework for motion at European level and builds on the European Pact for Mental Well being and Well-being.

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