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Although the presently most well-liked embodiment of the invention contemplates using the phosphodiesterase inhibitor sildenafil citrate as the preferred active for the methods set forth herein in the therapy and/or prevention of EIPH, it's particularly contemplated that different phosphodiesterase inhibitors are throughout the scope of the invention. Particularly, the invention relates to methods and gadgets for nebulization therapy in horses for the remedy and prevention of respiratory situations including Exercise-Induced Pulmonary Hemorrhage (EIPH) and related pulmonary sequella in the horse. The foregoing and different objects, features and advantages of the present invention should grow to be apparent to those of talent within the art in the following description when taken along with the accompanying drawings and through apply of the invention. Accordingly, there still exists a need in the artwork for such strategies. In the embodiment proven, in FIG. 1, the gadget 10 and attachment means 20 are proven connected to the top 30 of the subject equine and lying beneath a typical equine halter 60. Thus, one among ability within the art can respect that the gadget 10 and attachment means 20 may be attached and used independent of but along with halters, bridles or other equine head gear.

Within the embodiment proven in FIG. 1, the attachment means 20 itself is a halter-sort or halter-like apparatus constructed of nylon or leather with adjustable straps for securing to the top 30 of the topic equine and is separate from halter 60. As set forth extra filly beneath, the attachment means 20 for the gadget 10 may be separate from halter 60 or built-in therein. The system 10 or equine nasal cannula can be designed to conform to or become an integral part of harness and/or bridle or other halter-sort tools usually related to the coaching and racing of equine athletes. Thus, the current invention gives an inhalation therapy regimen administered via, e.g., a non-invasive equine nasal cannula system as additionally provided by the invention. In a presently most well-liked embodiment, the invention supplies a method for the remedy or prevention of EIPH, wherein the composition for inhalant therapy is a mixture comprised of sildenafil citrate or its congeners (e.g., metabolites, isomers, salts or other active derivatives of sildenafil citrate) using air because the delivery automobile to carry the inhalant into the equine mammal. In a single embodiment, the therapy regimen contains the introduction of a composition comprised of sildenafil citrate or congeners of sildenafil citrate with or with out potentiating brokers delivered to the subject equine by way of the attendant inhalation therapy system in a non-invasive manner that's conducive to the care and comfort of the equine mammal under treatment.

The system 10 is held in place by attachment means 20 such that the distal ends 16, 18 of elongated delivery tubes 12, 14 (cannulas) are positioned adjacent the exterior openings 32, 34 of the subject equine's nasal cavity (adjacent the nares) in order to effectively ship the composition selected for inhalation at the suitable site. Within the presently most well-liked embodiment, the gadget 10 of the invention (the equine nasal cannula) is comprised of a nylon attachment means 20 (similar to a halter) that is configured to adapt to the contours of the equine skull 30 in such a manner as to effectively place and hold the distal ends 16, 18 of the elongated delivery tubes 12, 14 in a desired place for the administration of a therapeutic inhalant while minimizing the necessities for specialized animal restraint and/or restriction of movement. In a single embodiment, padded extrusions (not proven) are provided on the distal ends 16, 18 (nasal end) of the elongated tubes 12, 14 (cannulas) to stop damage or irritation which will happen from rubbing the nostrils or the inner linings (mucosa) of the nostrils.

Thus, the dimensional and different characteristics shown in FIGS. FIG. 5 is a perspective view of one embodiment of the nebulization apparatus and air supply for delivery of a desired therapeutic agent through the machine of FIGS. FIG. 3 is a perspective view of one embodiment of the nasal cannula portion of the gadget of the invention. FIG. 7 is a coloration digital photograph exhibiting a left frontal view of 1 embodiment of the device of the invention. It is an object of the invention to provide an inhalation therapy regimen and system for the treatment and/or prevention of EIPH comprising the inhalation of a therapeutic quantity of sildenafil citrate and/or the metabolites of sildenafil citrate alone or together with different compounds. Studied for its immune well being advantages, N-Acetyl-L-Cysteine 98% wholesale defends against insults from overseas compounds. Generally speaking, easy organic compounds formed by the alternative of a hydrogen atom of hydrogen sulfide by an aliphatic, aromatic or heterocyclic radical are known as "thiols," e.g. methanethiol; whereas, polyfunctional compounds so formed are often described with the prefix "mercapto," such as mercaptoacetic acid.